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. 2019 Apr 29;2019(4):CD001808. doi: 10.1002/14651858.CD001808.pub3

Adhikari 2007.

Methods Quasi‐randomised controlled trial.
 Women were allotted consecutively into Group A or B in the second stage when quote: “delivery imminent.” Participants were not blinded.
Participants Women presenting for delivery at the Tribhuvan University Teaching Hospital in Nepal over a 1‐year period in 2004.
All women with parity < 5, singleton live pregnancy at or above 37 weeks, cephalic, with spontaneous onset of labour and spontaneous vaginal delivery without complicating factors were included. Women with the following were excluded: parity > 4, multiple gestation, < 37 weeks, women with “complicating factors” (not specified). Women were excluded if they had an instrumental or caesarean delivery, precipitous labour or lack of postpartum blood sample.
Interventions Immediately after delivery participants received:
A. oxytocin 10 IU IM (n = 100) or
B. methylergometrine 0.2 mg IM (n = 100)
All received early cord clamping, cord traction, and uterine massage.
Outcomes Mean decrease in Hb/Hct measurements between admission in labour and 24 hours postpartum, incidence of PPH (defined as peripartum fall in Hct of 10%), need for additional uterotonics, need for exploration and uterine evacuation, blood transfusion, nausea, vomiting, headache, retained placenta (need for manual removal), rise in blood pressure (systolic > 15 mmHg and diastolic > 10 mmHg)
Notes Dates of study: 2004
Funding sources: not reported
Declarations of interest: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Quasi‐randomisation, quote:“women were allotted consecutively into two groups at the second stage of labour…if the first woman was enrolled into Group A then the next would be in Group B and so on.”
Allocation concealment (selection bias) High risk Alternation of assignment into Group A and B: quote: “women were allotted consecutively into two groups at the second stage of labour…if the first woman was enrolled into Group A then the next would be in Group B and so on.”
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not blinded.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Not blinded.
Incomplete outcome data (attrition bias) 
 All outcomes High risk Women were excluded after randomisation, however the authors do not clarify how many were lost from each group and how this attrition was addressed.
Selective reporting (reporting bias) Unclear risk Insufficient information to assess.
Other bias Unclear risk Unclear.