McGinty 1956.

Methods	Randomised trial. 'Cases picked at random'. Unblinded.
Participants	All vaginally delivered under pudendal block and demerol/scopolamine, in hospital in the USA.
Interventions	Drug given at birth of anterior shoulder: A. 1 mL normal saline intravenously (n = 50); B. 0.2 mg methergine intravenously (n = 50); C. 0.2 mg ergonovine intravenously (n = 50); D. oxytocin 5 IU each intravenously and intramuscularly (n = 50). Comparisons for this review: D vs B and C. Data not provided for control group so this group was not included in this review. No information about other aspects of third stage management.
Outcomes	Diastolic and systolic blood pressure 5, 15 and 60 minutes after administration; estimated severe blood loss over 1000 mL mentioned for 1 women in methergine series and 1 in control group (not included in data tables as unlikely to have been systematically recorded).
Notes	Dates of study: not reported Funding sources: quote: “All Methergine used in this study was supplied through the courtesy of Sandoz Pharmaceuticals, New York, New York.” Declarations of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Cases picked at random". Randomisation technique not described.
Allocation concealment (selection bias)	Unclear risk	Allocation concealment not described.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not explicitly described, although some instances where blinding of personnel breached mentioned which suggests inadequate blinding.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	200 patients recruited, and data for all 200 individuals reported.
Selective reporting (reporting bias)	Unclear risk	Protocol unseen.
Other bias	Unclear risk	Unclear.