Orji 2008.

Methods	Randomised controlled trial. Eligible participants who gave informed consent were randomly allocated to either oxytocin or ergometrine group. Allocation was done by opening a sealed envelope from a pack that had been arranged serially. Not blinded.
Participants	600 consenting women in labour with no illnesses or added risk in the active phase at 2 tertiary hospitals in Nigeria. Excluded those with hypertensive disorders of pregnancy, packed cell volume < 30%, history of PPH, haemoglobinopathy, heart disease or caesarean section.
Interventions	At delivery of the anterior shoulder: A. oxytocin 10 IU IV (n = 297); B. ergometrine 0.25 mg IV (n = 303). In both groups the third stage of labour was managed actively. Blood loss was measured using a pre‐weighed guaze that was weighed again after delivery.
Outcomes	Primary outcomes: PPH (> 500 mL), severe PPH (> 1000 mL). Secondary outcomes: retained placenta, need for blood transfusion, manual placental removal, estimated blood loss (mL), nausea, vomiting, headaches, elevated blood pressure, need for additional uterotonics.
Notes	Dates of study: January 2006 to September 2007 Funding sources: not reported Declarations of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomly assigned to previously determined sequence.
Allocation concealment (selection bias)	Low risk	Quote: "...sealed envelopes arranged serially...".
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not mentioned in report assumed not due to different doses of drug being given.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not mentioned in report
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data appear to be reported for all participants. No loss to follow‐up reported.
Selective reporting (reporting bias)	Unclear risk	Protocol unseen but all outcomes pre‐specified in methods text are reported
Other bias	Unclear risk	No data.