Table 2.
Urine excretion of atenolol
| Subject Code | Day | Dose administered | Atenolol excretion | Total atenolol excretion (mg) | % atenolol excretion over | Rate of atenolol excretion | |
|---|---|---|---|---|---|---|---|
| (mg) | (µg/mL) | 5 (h) 510 (h) | 10 (h) | (mg/h) | |||
| 1 | 50 | 135.7 | 4.9 | 16.2 | 42.2 | 4.2 | |
| 12 | 2 | 75 | 74 | 3.8 | 21 | 33 | 4.9 |
| 3 | 100 | 99.2 | 3.1 | 10.4 | 31.5 | 6.3 | |
| Mean | 102.9 | 3.9 | 15.8 | 35.5 | 5.1 | ||
| 1 | 50 | 253 | 9.2 | 18 | 42.2 | 5.4 | |
| 22 | 2 | 75 | 77 | 14.4 | 17.2 | 47.2 | 6.4 |
| 3 | 100 | 607.6 | 11 | 41 | 25 | 10.4 | |
| Mean | 312. 5 | 11.5 | 25.4 | 38.1 | 7.4 | ||
| 1 | 50 | 46.5 | 8.9 | 3.5 | 23 | 2.3 | |
| 32 | 2 | 75 | 9.3 | 2.7 | 0.5 | 4.4 | 0.6 |
| 3 | 100 | 13.6 | 0.6 | 3.6 | 4.2 | 0.8 | |
| Mean | 23.2 | 4 | 2.6 | 10.4 | 1.3 | ||
| 1 | 50 | 24.9 | 10.9 | 3.2 | 28 | 2.8 | |
| 42 | 2 | 75 | 2.8 | 0.6 | 0.7 | 1.7 | 0.3 |
| 3 | 100 | 16.2 | 0.3 | 2.8 | 3.2 | 0.6 | |
| Mean | 14. 6 | 3.9 | 2.2 | 10.9 | 1.2 | ||
| 1 | 50 | 2.9 | 0.03 | 1.5 | 3.1 | 0.3 | |
| 52 | 2 | 75 | 5.3 | 0.5 | 0.9 | 1.9 | 0.3 |
| 3 | 100 | 1.5 | 0.2 | 0.4 | 0.6 | 0.11 | |
| Mean | 3.2 | 0.3 | 0.9 | 1.9 | 0.2 | ||