Table 1.
1H and 13C NMR data of compounds 1 and 2 in CDCl /CD OD (500 MHz for δ ; 125 MHz for δ )
|
1
|
2
|
|||
|---|---|---|---|---|
| position | δ C | δ H (J in Hz) | δ C | δ H (J in Hz) |
| 1α 1β | 41.6 | 0.85b 1.52b |
40.0 | 0.88b 1.53b |
| 2α 2β | 18.3 | 1.60b 1.33b |
18.4 | 1.53b 1.35b |
| 3α 3β | 44.1 | 1.05b 1.22b |
41.8 | 1.07b 1.28b |
| 4 | 33.4 | 32.9 | ||
| 5α | 56.7 | 0.83b | 56.7 | 0.83b |
| 6α 6β | 67.6 | 4.39 brd (2.6) | 20.6 | 1.57b 1.18b |
| 7α 7β | 51.3 | 1.55b 1.91 dd (13.5, 2.0) |
43.8 | 1.34b 1.75 dt (12.5,3.0) |
| 8 | 73.4 | 74.5 | ||
| 9α | 62.1 | 1.03b | 62.3 | 1.00 t (3.5) |
| 10 | 38.9 | 39.2 | ||
| 11α 11β | 17.9 | 1.49 1.28 |
18.0 | 1.46b 1.26b |
| 12α 12β | 40.9 | 1.60b 1.41b |
40.8 | 1.60b 1.38b |
| 13 | 73.1 | 73.8 | ||
| 14β | 75.1 | 3.55 dd (8.5, 2.5) | 77.8 | 3.39 dd (7.5, 3.5) |
| 15a 15b | 66.2 | 3.96 dd (11.5, 8.5) 4.22 dd (11.5, 2.5) |
62.5 | 3.50 dd (11.5, 7.5) 3.65 dd (11.5, 3.5) |
| 16 | 22.6 | 1.10 s | 22.0 | 1.08 s |
| 17 | 24.8 | 1.32 s | 23.6 | 1.09 s |
| 18 | 32.8 | 0.89 s | 33.4 | 0.79 s |
| 19 | 24.2 | 1.10 s | 21.5 | 0.71 s |
| 20 | 16.1 | 1.08 s | 14.9 | 0.73 s |
| CH3CO CH3CO | 19.8 171.3 |
1.99 s | ||
a
δ values were extracted from COSY, HSQC and HMBC experiments.
b
Overlapping signals.