Table 4.
Polymerosomes formulation contains DTX with different proportions of CL15 and LA15
| No. | CL5% | LA5% | Z-Average (nm) | PdI | Zeta potential (mV) | DTX (µg/mL) | EE% | LC% |
|---|---|---|---|---|---|---|---|---|
| M1 a | 100 | 0 | 48.69 ± 4.2 | 0.445 ± 0.1 | -6.14 | 114.7 ± 0.1 | 57.35 ± 0.25 | 0.57 ± 0.04 |
| M2 b | 0 | 100 | 36.19 ± 7.8 | 0.249 ± 0.04 | -7.62 | 92 ± 0.02 | 46 ± 0.03 | 0.46 ± 0.02 |
| M3 c | 50 | 50 | 31.36 ± 5.6 | 0.233 ± 0.09 | -18.9 | 113 ± 0.35 | 56.5 ± 0.07 | 0.56 ± 0.07 |
| M4 d | 25 | 75 | 36.4 ± 6.8 | 0.344 ± 0.05 | -16.6 | 100 ± 0.02 | 50 ± 0.62 | 0.50 ± 0.01 |
| M5 e | 75 | 25 | 32.65 ± 8.3 | 0.262 ± 0.02 | -12.7 | 174 ± 0.03 | 87 ± 0.09 | 0.87 ± 0.09 |
a) P1: Polymersome contains 100 % CL15 and 0 % LA15.
b) P2: Polymersome contains 0 % CL15 and 100 % LA15.
c) P3: Polymersome contains 50 % CL15 and 50 % LA15.
d) P4: Polymersome contains 25 % CL15 and 75 % LA15.
e) P5: Polymersome contains 75 % CL15and 25 % LA15.