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. Author manuscript; available in PMC: 2019 Apr 29.
Published in final edited form as: Curr Opin Cell Biol. 2018 Jun 11;54:114–120. doi: 10.1016/j.ceb.2018.05.004

Figure 3: Model for the actions of AMPK in a migrating cell.

Figure 3:

The leading edge or lamellipodium of a migrating cell is integrin-rich nascent adhesions and mitochondria. In this region, AMPK stimulates mitochondria flux, ATP production and cytoskeletal dynamics. Behind the leading edge is a transition zone where the nascent adhesions mature or disassemble. Mature focal adhesions are present further back in the cell in the lamellum. In mature adhesions, AMPK inhibits integrin activity and mechanotransduction.