Table 2.

Levels of primary and secondary bile acids measured in the ADNI cohort stratified by clinical diagnosis^a.

Bile Acid	Category	Nb	CN (N=370)	EMCI (N=284)	LMCI (N=505)	AD (N=305)
CA, Cholic	Primary	1446	0.221(0.024)	0.155(0.021)	0.192(0.021)	0.135(0.025)
CDCA, Chenodeoxycholic	Primary	1357	0.285(0.042)	0.241(0.034)	0.288(0.033)	0.216(0.033)
GCA, Glycocholic	Primary Conjugated	1463	0.236(0.019)	0.234(0.021)	0.239(0.014)	0.297(0.037)
GCDCA, Glycochenodeoxycholic	Primary Conjugated	1464	0.658(0.035)	0.724(0.059)	0.710(0.037)	0.806(0.049)
TCA, Taurocholic	Primary Conjugated	1020	0.068(0.008)	0.057(0.006)	0.068(0.006)	0.066(0.009)
TCDCA, Taurochenodeoxycholic	Primary Conjugated	1426	0.090(0.006)	0.088(0.007)	0.091(0.006)	0.097(0.008)
TMCA, Tauromuricholic	Primary Conjugated	1146	0.012(0.001)	0.011(0.001)	0.014(0.002)	0.014(0.002)
DCA, Deoxycholic	Secondary	1445	0.526(0.041)	0.574(0.043)	0.529(0.026)	0.627(0.045)
UDCA, Ursodeoxycholic	Secondary	1111	0.065(0.007)	0.072(0.011)	0.091(0.010)	0.087(0.012)
GDCA, Glycodeoxycholic	Secondary Conjugated	1439	0.440(0.034)	0.488(0.038)	0.502(0.031)	0.672(0.054)
TDCA, Taurodeoxycholic	Secondary Conjugated	1430	0.058(0.006)	0.059(0.005)	0.065(0.005)	0.077(0.006)
GLCA, Glycolithocholic	Secondary Conjugated	1037	0.027(0.002)	0.034(0.003)	0.030(0.002)	0.039(0.003)
TLCA, Taurolithocholic	Secondary Conjugated	1008	0.005(0.0002)	0.005(0.0003)	0.005(0.0003)	0.006(0.0005)
GUDCA, Glycoursodeoxycholic	Secondary Conjugated	1401	0.115(0.010)	0.114(0.012)	0.129(0.012)	0.136(0.015)
TUDCA, Tauroursodeoxycholic	Secondary Conjugated	1369	0.008(0.001)	0.008(0.001)	0.008(0.001)	0.008(0.001)

^aValues represent μM in mean (standard error of the mean).

^bNumber of non-missing measurements.