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. 2019 Apr 29;7:66. doi: 10.1186/s40478-019-0720-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Representative cases of PIK3CA mutant glioblastomas demonstrating widespread disease at presentation. a The tumors were multicentric, affecting the left frontal and left parietal lobes without any intervening T2/fluid attenuated inversion recovery abnormality. b The tumor diffusely involved multiple lobes including the right frontal, parietal, and occipital lobes as well as the left parietal lobe. c The main tumor was located in the left posterior mesial temporal lobe with leptomeningeal involvement of the adjacent brain such as the midbrain and pons. Distant lesions were also observed on the ventral surface of the pons and the dorsal surface of the cervical spinal cord