Table 1.
Patient and tumor characteristics
| Total | PIK3CA mutant | PIK3CA wildtype | P value | |
|---|---|---|---|---|
| Number of patients | 157 | 13 | 144 | |
| (male patient) | (91 male) | (9 male) | (82 male) | 0.56 |
| Age | median 58 (23–85) | mean 49.4 ± 15.9 | mean 58.1 ± 12.1 | 0.02* |
| KPS score | median 90 (60–100) | mean 92.3 ± 7.3 | mean 87.7 ± 10.4 | 0.048* |
| Gross total resection | 69 (44.0%) | 5 (38.5%) | 64 (44.4%) | 0.78 |
| IDH1 mutation | 12/157 (7.6%) | 0/13 (0.0%) | 12/144 (8.3%) | 0.60 |
| MGMT promoter methylation | 60/120 (50.0%) | 8/11 (72.7%) | 52/109 (47.7%) | 0.20 |
| EGFR amplification | 63/143 (44.1%) | 2/12 (16.7%) | 61/131 (46.6%) | 0.07 |
* Statistical significance: P ≤ 0.05
Abbreviations: KPS, Karnofsky performance status; IDH1, isocitrate dehydrogenase 1; MGMT O6-methylguanine-DNA methyltransferase