Table 2.

PIK3CA mutation was significantly associated with shorter survival after adjusting for age, KPS, gross total resection, IDH1 mutation, and MGMT promoter methylation

	Univariate analysis	Multivariate analysis
	P value	P value	HR
[PFS]
High age	0.0004*	0.005*	1.03 (1.01–1.05)#
High KPS score	0.10	0.28	0.99 (0.97–1.01)#
Gross total resection	0.02*	0.17	0.75 (0.49–1.13)
PIK3CA mutation	0.03*	0.01*	2.89 (1.30–5.90)
IDH1 mutation	< 0.0001*	0.002*	0.10 (0.006–0.50)
MGMT promoter methylation	< 0.0001*	< 0.0001*	0.33 (0.21–0.52)
[OS]
High age	0.0004*	0.003*	1.03 (1.01–1.05)#
High KPS score	0.047*	0.32	0.99 (0.96–1.01)#
Gross total resection	0.11	0.53	0.87 (0.55–1.35)
PIK3CA mutation	0.19	0.049*	2.32 (1.00–4.88)
IDH1 mutation	< 0.0001*	0.02*	0.15 (0.008–0.74)
MGMT promoter methylation	< 0.0001*	< 0.0001*	0.27 (0.17–0.44)

* Statistical significance: P ≤ 0.05

^# HR per unit

Abbreviations: PFS, progression-free survival; OS, overall survival; KPS, Karnofsky performance status; IDH1, isocitrate dehydrogenase 1; MGMT, O⁶-methylguanine-DNA methyltransferase; HR, hazard ratio