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. 2019 Apr 29;7:65. doi: 10.1186/s40478-019-0710-x

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Ref1 mRNA level is increased in Drosophila ALS/FTD models. a Ref1 mRNA levels in Drosophila heads are increased by TDP-43 expression. *p < 0.05 two tailed Student’s t-test. Genotypes. Control: elavGS/+. TDP-43: elavGS/UAS-TDP-43. b Ref1 mRNA levels in Drosophila heads are increased by long (49), but not short (8) G4C2 repeats expression. One-way ANOVA with Dunnett’s multiple comparisons test, F(2,15) = 52.09, p < 0.001. ***p < 0.001, n.s not statistically significant. Genotypes. Control: elavGS/+. (G4C2)8: elavGS/UAS-(G4C2)8. (G4C2)49: elavGS/UAS-(G4C2)49. For all graphs, individual data points are shown with mean +/− standard deviation