Figure 5.
Inhibition of MAGL by MJN110 reduces basal small intestinal transit. Pretreatment feeding and food intake following gavage were not affected by MJN110 (MJN; 10 mg·kg−1) administration in unstressed (A,B; n = 5) and stressed rats (D,E; n = 9), compared to vehicle pretreated animals that underwent 2 h restraint (n = 12) or remained in their homecage (n = 4). However, MAGL inhibition significantly reduced small intestinal transit in unstressed rats (C), while transit remained unchanged by MJN110 pretreatment following stress (F). Individual results are shown with mean ± SEM indicated by the bars. *P = 0.05, significantly different from VEH.