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. 2018 Aug 22;176(10):1524–1540. doi: 10.1111/bph.14453

Figure 7.

Figure 7

Dual FAAH/MAGL inhibition stimulates food intake. In unstressed rats, combined i.c.v. administration of PF‐04457845 (PF; 3 μg) and MJN110 (MJN; 5 μg) (n = 8) increased early feeding at 1 h (A) compared to animals that received vehicle (n = 14), however, body weight was not significantly increased with combined treatment (C). In stressed animals, combined PF‐04457845 and MJN110 pretreatment (n = 8) had no effect on feeding (D,E) or body weight (E) compared to vehicle pretreated rats (n = 16). Individual results are shown with mean ± SEM indicated by the bars. *P < 0.05, significantly different from VEH.