Figure 8.

Central FAAH inhibition attenuates stress‐induced anorexia via CB₁ receptors and reduces homeostatic feeding independent of CB₁ signalling. In unstressed rats, i.c.v. administration of PF‐04457845 (PF; 30 μg; n = 13) or PF‐04457845 combined with AM251 (0.1 μg; n = 8) reduced early feeding (A) compared to animals receiving vehicle (n = 12). Among stressed animals, rats administered i.c.v. PF‐04457845 (PF; n = 13) consumed more food at 2 h post‐stress (D) compared to rats receiving vehicle (n = 13) or PF‐04457845 combined with AM251 (n = 9). Individual results are shown with mean ± SEM indicated by the bars. *P < 0.05, significantly different as indicated.