Table 3.

Estimated binding affinities for ligands docked to CB₁ receptor and CB₂ receptor models 5XRA and 5TGZ

Ligand	CB1 receptor‐5XRA		CB1 receptor‐5TGZ		Ligand	CB2 receptor‐5XRA		CB2 receptor‐5TGZ
	Estimated Affinity (kcal·mol−1)	Estimated K A (nM)	Estimated Affinity (kcal·mol−1)	Estimated K A (nM)		Estimated Affinity (kcal·mol−1)	Estimated K A (nM)	Estimated Affinity (kcal·mol−1)	Estimated K A (nM)
CP55,940	−10.9	20.8	−11.2	12.8	CP55,940	−10.6	33.9	−9.8	124
2‐AG	−8.4	1200	−9.6	171	2‐AG	−8.7	740	−8.7	740
THC	−8.7	741	−10.4	46.9	THC	−10.5	39.9	−8.8	629
CBD	−7.1	9930	−9.7	146	CBD	−9.4	238	−8.9	535
CBD‐DMH	−8.9	535	−9.4	238	CBD‐DMH	−9.4	238	−9.7	146
Org27569	−10.2	64.9	−9	454	SR144528	−10.4	46.9	−11.5	7.87