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. 2018 Mar 1;176(10):1552–1567. doi: 10.1111/bph.14147

Figure 4.

Figure 4

Effects of SR141716‐precipitated withdrawal from chronic administration of WIN‐55212, CBD or their combination. Acute administration of SR141716 significantly increase scratching, paw tremor and head shakes compared to acute vehicle administration. Scratching and head shakes are attenuated in mice chronically treated with WIN or WIN+CBD. Chronic WIN and WIN+CBD administration also led to significant decreases in rearing. N = 8 per group. + P < 0.05, significantly different from Veh + Veh; * P < 0.05, significantly different from Veh + SR; # P < 0.05, significantly different from WIN+CBD; one‐way ANOVA.