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. 2019 Apr 26;2(4):e192906. doi: 10.1001/jamanetworkopen.2019.2906

Figure 3. Summary of the Molecular Profiling of Patients in Oncogene Gene Category.

Figure 3.

Data were derived from all 62 patients with completed whole-exome sequencing as well as RNA sequencing of tumors and whole-exome sequencing of germline DNA. The presence of specific mutations, insertion/deletions (indels), amplification/deletions, and genes fusions are indicated by colored circles for hematological malignant neoplasms and solid tumors. Only sequencing findings with biological significance are included. Somatic type included somatic single-nucleotide variants or indels. Sarcoma included rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, round cell sarcoma. Brain type included pilocytic astrocytoma medulloblastoma. Other types included malignant rhaboid tumor, adrenal gland carcinoma, hepatoblastoma, paraganglioma, Wilms tumor, sinus carcinoma, hepatocarcinoma, pleuropulmonary blastoma, NUT midline carcinoma, epithelial tumor, and gastric NET. ALL indicates acute lymphoblastic leukemia; AML, acute myeloid leukemia; LOH, loss of heterozygosity; NB, neuroblastoma; NET, neuroendocrine tumors; NUT, nuclear protein of the testis.