Figure 1.

Animal weight (panel A) and rotarod performance (panel B) of TDP‐43 (A315T) transgenic and wild‐type male mice after the daily treatment with WIN55,212‐2 (5 mg·kg⁻¹) or vehicle from day 65 up to day 90 after birth. Quantification of Nissl‐stained motor neurons (panel D), including representative images, in which the area analysed is marked by a circle (panel C; scale bar = 300 μm), in the lumbar ventral horn of the spinal cord in the three experimental groups once animals were killed 24 h after the last injection. In all cases, values are means ± SEM of 12 animals per group. Data were assessed by one‐way (Nissl staining) and repeated measures two‐way (weight and rotarod) ANOVA followed by the Bonferroni test (*P < 0.05 vs. wild type).