In system S1b, Aβ interacted with the membrane only transiently. (a) The number of hydrogen bonds, NHB, established between layer 1 and layer 2 (red) compared to the NHB between layer 1 and the lipids (black), and (b) the electrostatic energy (Ue) between D23 and K28 in layer 1 (green) and between D23, K28 in layer 1 and the lipids (black).