Table 4:
Adjusteda percent change (95% confidence interval) in urinary 8-iso-PGF2α, PGF2α, and F2-IsoP-M in association with an interquartile range increase in urinary phthalate and DINCH metabolite concentrations.
| 8-iso-PGF2α | PGF2α | F2-IsoP-M | ||||||
|---|---|---|---|---|---|---|---|---|
| Parent | Metabolite | %Δ (95% CI) | p | %Δ (95% CI) | p | %Δ (95% CI) | p | |
| Phthalates | DEP | MEP | 4.48 (−1.1,10.36) | 0.1 | 2.83 (−4.66,10.91) | 0.5 | 5.39 (0.96,10) | 0.02 |
| DBP | MBP | 15.27 (9.62,21.21) | <0.01 | 6.07 (−1.16,13.84) | 0.1 | 9.98 (5.7,14.43) | <0.01 | |
| MHBP | 8.04 (2.39,13.99) | <0.01 | 5.81 (−1.79,14.01) | 0.1 | 4.63 (0.42,9.03) | 0.03 | ||
| BzBP | MBzP | 12.99 (6.67,19.69) | <0.01 | 3.13 (−4.83,11.76) | 0.5 | 10.39 (5.52,15.48) | <0.01 | |
| DiBP | MiBP | 17.79 (12.52,23.31) | <0.01 | 9.29 (2.42,16.62) | <0.01 | 12.06 (8.08,16.18) | <0.01 | |
| MHiBP | 11.96 (6.59,17.61) | <0.01 | 6.02 (−1.06,13.61) | 0.1 | 6.6 (2.63,10.72) | <0.01 | ||
| DEHP | MECPP | 11.68 (6.89,16.69) | <0.01 | 5.01 (−1.25,11.66) | 0.1 | 9.29 (5.59,13.11) | <0.01 | |
| MEHHP | 8.5 (3.84,13.37) | <0.01 | 0.88 (−5.1,7.23) | 0.8 | 6.2 (2.6,9.92) | <0.01 | ||
| MEOHP | 9.42 (4.48,14.6) | <0.01 | 1.49 (−4.84,8.23) | 0.7 | 6.78 (2.97,10.72) | <0.01 | ||
| MEHP | 9.26 (4.32,14.43) | <0.01 | 7.99 (1.29,15.15) | 0.02 | 4.23 (0.5,8.11) | 0.03 | ||
| ΣDEHP | 12.19 (6.63,18.04) | <0.01 | 4.42 (−2.74,12.1) | 0.2 | 9.04 (4.78,13.48) | <0.01 | ||
| DEHTP | MECPTP | 10.63 (5.19,16.34) | <0.01 | 9.31 (1.9,17.26) | 0.01 | 3.35 (−0.59,7.45) | 0.1 | |
| MEHHTP b | 17.74 (6.64,29.99) | <0.01 | 21.68 (6.09,39.57) | <0.01 | 10.32 (2.25,19.02) | 0.01 | ||
| DOP | MCPP | 5.29 (0.37,10.44) | 0.04 | 3.61 (−3.01,10.69) | 0.3 | 5.4 (1.53,9.42) | <0.01 | |
| DNP | MCOP | 13.06 (6.79,19.7) | <0.01 | 7.32 (−0.88,16.19) | 0.08 | 9.38 (4.59,14.39) | <0.01 | |
| MNP* | 11.72 (1.67,22.77) | 0.02 | 20.3 (5.63,37) | <0.01 | 7.3 (−0.17,15.32) | 0.06 | ||
| MONP | 6.62 (0.5,13.12) | 0.03 | 2.61 (−5.47,11.38) | 0.5 | 3.38 (−1.2,8.17) | 0.2 | ||
| DDP | MCNP | 8.75 (4.02,13.7) | <0.01 | 13.54 (6.8,20.71) | <0.01 | 5.99 (2.35,9.76) | <0.01 | |
| Phthalate alternative | DINCH | MHiNCH b | 3.69 (−5.01,13.18) | 0.4 | 27.57 (13.21,43.75) | <0.01 | 16.18 (8.56,24.32) | <0.01 |
| MCOCH b | 9.02 (−1.51,20.67) | 0.1 | 31.81 (14.73,51.44) | <0.01 | 17.26 (8.61,26.6) | <0.01 | ||
a
Models adjusted for maternal Race/Ethnicity, education, income, and body mass index. Phthalate and DINCH metabolites, oxidative stress biomarkers are corrected for urinary specific gravity.
b
These metabolites are modeled dichotomously as above or below LOD instead of numerically