Table 3 -.

Hazard ratios for hip fracture by subclinical vascular disease in the presence of clinical cardiovascular disease.

			All			Men			Women
	N	Fx	HR	95%CI	p-val	HR	95%CI	p-val	HR	95%CI	p-val
ABI*	1364	144
Model 0			0.57	(0.26,1.26)	0.17	0.70	(0.20,2.41)	0.57	0.50	(0.18,1.42)	0.19
Model 1			0.63	(0.27,1.45)	0.28	0.70	(0.19,2.52)	0.58	0.58	(0.19,1.77)	0.34
Model 2			0.84	(0.33, 2.09)	0.70	0.71	(0.18,2.85)	0.63	0.86	(0.25,3.01)	0.82
CD **	1387	146
Model 0			1.29	(1.08,1.54)	0.006	1.27	(0.95,1.69)	0.11	1.30	(1.03,1.64)	0.03
Model 1			1.26	(1.04,1.53)	0.02	1.27	(0.95,1.72)	0.11	1.25	(0.98,1.61)	0.07
Model 2			1.25	(1.02,1.53)	0.03	1.31	(0.97,1.78)	0.08	1.18	(0.90,1.54)	0.23
AWT ***	1338	142
Model 0			1.10	(1.05,1.16)	<0.001	1.09	(1.03,1.16)	0.007	1.15	(1.05,1.26)	0.003
Model 1			1.11	(1.05,1.17)	<0.001	1.10	(1.03,1.17)	0.006	1.14	(1.04,1.26)	0.008
Model 2			1.11	(1.05,1.17)	<0.001	1.08	(1.01,1.16)	0.027	1.15	(1.04,1.27)	0.006

The hazards ratios for hip fractures are per unit increase in the predictor:

^*Per 1 unit increase in the ratio (index) of the ankle to brachial blood pressures.

^**Per one average standard deviation increase of IMT – i.e., standard deviations away from the mean IMT variable.

^***Per 1mm increase in both walls of the aorta.

ABI – ankle arm index; CD – carotid artery disease; AWT – aortic wall thickness; N – number at risk; Fx – number of hip fractures

Model 0 – age, sex and race;

Model 1 – Model 0 + current smoking + alcohol (0 ref, 1–7, >7 drinks);

Model 2 – Model 1 + weight (kg) + diabetes+ hypertension+ eGFR cystatin + estrogen (females) + history of falling in the year before baseline