Table 2.
mRNA GO analysis in metastatic melanoma.
| Biological process | Cellular component | ||||||
|---|---|---|---|---|---|---|---|
| GOID | GO name | Diff/count | FDR | GOID | GO name | Diff/count | FDR |
| GO: 0030216 | Keratinocyte differentiation | 147/752 | 2.81E-117 | GO: 0001533 | Cornified envelope | 51/807 | 2.98E-55 |
| GO: 0031424 | Keratinization | 131/752 | 5.73E-117 | GO: 0045095 | Keratin filament | 60/807 | 1.12E-54 |
| GO: 0043588 | Skin development | 163/752 | 5.84E-113 | GO: 0005882 | Intermediate filament | 76/807 | 9.18E-50 |
| GO: 0008544 | Epidermis development | 168/752 | 9.59E-111 | GO: 0045111 | Intermediate filament cytoskeleton | 79/807 | 6.20E-47 |
| GO: 0009913 | Epidermal cell differentiation | 149/752 | 1.75E-108 | GO: 0030057 | Desmosome | 14/807 | 2.03E-11 |
| GO: 0070268 | Cornification | 67/752 | 3.69E-59 | GO: 0042599 | Lamellar body | 10/807 | 1.12E-07 |
| GO: 0018149 | Peptide cross-linking | 39/752 | 2.35E-36 | GO: 0097209 | Epidermal lamellar body | 4/807 | 0.00022698 |
| GO: 0019730 | Antimicrobial humoral response | 29/752 | 3.21E-13 | GO: 0005911 | Cell-cell junction | 38/807 | 0.001175796 |
| GO: 0061436 | Establishment of skin barrier | 14/752 | 1.31E-12 | GO: 0034707 | Chloride channel complex | 9/807 | 0.011451671 |
| GO: 0033561 | Regulation of water loss via skin | 14/752 | 8.98E-12 | GO: 0034702 | Ion channel complex | 26/807 | 0.016861797 |