Table 2.
Predictors of CMSS obtained from stepwise Cox regression analysis in the MDACC study
| Parametera | Categoryb | Frequency | HR (95% CI) | P |
|---|---|---|---|---|
| Age | ≤50/>50 | 371/487 | 1.02 (1.01–1.04) | 0.0090 |
| Sex | Female/Male | 362/496 | 1.55 (0.97–2.47) | 0.0677 |
| Regional/distant metastasis | No/Yes | 709/149 | 4.52 (2.92–6.99) | <0.0001 |
| Breslow thickness (mm) | ≤1/>1 | 347/511 | 1.16 (1.10–1.22) | <0.0001 |
| Ulceration | No/Yes | 681/155 | 2.79 (1.81–4.29) | <0.0001 |
| Mitotic rate (mm2) | ≤1/>1 | 275/583 | 2.53 (1.21–5.29) | 0.0137 |
| PDE1A rs6750552 T>C | TT/TC/CC | 388/376/94 | 1.48 (1.10–1.99) | 0.0104 |
| ITPR1 rs6785564 A>G | AA/AG/GG | 636/205/17 | 0.51 (0.32–0.80) | 0.0038 |
| RYR3 rs2596191 C>A | CC/CA/AA | 271/411/176 | 0.69 (0.51–0.93) | 0.0166 |
aStepwise analysis included age, sex, regional/distant metastasis, Breslow thickness, ulceration, mitotic rate and nine SNPs in four genes (rs485412, rs1104370, rs2841038 in CHRM3; rs6785564 in ITPR1; rs2596191 in RYR3 and rs2623439, rs1430157, rs6750552, rs10931014 in PDE1A).
bThe leftmost was used as the reference.