Table 3.
Associations between three independent SNPs and CMSS of patients in the MDACC study, the Harvard study and the combined dataset
| The MDACC Study (n = 858) | The Harvard Study (n = 409) | MDACC + Harvard (n = 1267) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | All | Death (%) | HR (95% CI)a | P a | All | Death (%) | HR (95% CI)b | P b | All | Death (%) | HR (95% CI)c | P c |
| PDE1A rs6750552 T>C | ||||||||||||
| TT | 388 | 37 (9.54) | 1.00 | 201 | 15 (7.46) | 1.00 | 589 | 52 (8.83) | 1.00 | |||
| TC | 376 | 45 (11.97) | 1.56 (0.99–2.46) | 0.053 | 169 | 28 (16.57) | 2.30 (1.23–4.30) | 0.010 | 545 | 73 (13.39) | 1.59 (1.12–2.27) | 0.010 |
| CC | 94 | 12 (13.83) | 2.06 (1.08–3.94) | 0.029 | 39 | 5 (12.82) | 2.03 (0.74–5.61) | 0.171 | 133 | 18 (13.53) | 1.74 (1.02–2.98) | 0.043 |
| Trend test | 0.013 | 0.022 | 0.007 | |||||||||
| TC+CC | 470 | 58 (12.34) | 1.65 (1.07–2.54) | 0.023 | 208 | 33 (15.87) | 2.25 (1.22–4.15) | 0.009 | 678 | 91 (13.42) | 1.62 (1.15–2.28) | 0.006 |
| ITPR1 rs6785564 A>G | ||||||||||||
| AA | 636 | 75 (11.79) | 1.00 | 299 | 41 (13.71) | 1.00 | 935 | 116 (12.41) | 1.00 | |||
| AG | 205 | 19 (9.27) | 0.58 (0.34–0.99) | 0.047 | 102 | 7 (6.86) | 0.47 (0.21–1.05) | 0.067 | 307 | 26 (8.47) | 0.65 (0.43–1.00) | 0.047 |
| GG | 17 | 1 (5.88) | 0.13 (0.02–0.98) | 0.048 | 8 | 0 (0.0) | — | — | 25 | 1 (4.00) | 0.28 (0.04–1.97) | 0.200 |
| Trend test | 0.004 | 0.040 | 0.019 | |||||||||
| AG+GG | 222 | 20 (9.01) | 0.50 (0.29–0.84) | 0.009 | 110 | 7 (6.36) | 0.44 (0.20–0.99) | 0.046 | 332 | 27 (8.13) | 0.62 (0.41–0.94) | 0.025 |
| RYR3 rs2596191 C>A | ||||||||||||
| CC | 271 | 38 (14.02) | 1.00 | 133 | 22 (16.54) | 1.00 | 404 | 60 (14.85) | 1.00 | |||
| CA | 411 | 45 (10.95) | 0.76 (0.48–1.19) | 0.227 | 205 | 21 (10.24) | 0.64 (0.35–1.16) | 0.137 | 616 | 66 (10.71) | 0.73 (0.51–1.03) | 0.071 |
| AA | 176 | 12 (6.82) | 0.44 (0.23–0.87) | 0.019 | 71 | 5 (7.04) | 0.41 (0.15–1.08) | 0.070 | 247 | 17 (6.88) | 0.46 (0.27–0.79) | 0.005 |
| Trend test | 0.016 | 0.039 | 0.003 | |||||||||
| CA+AA | 587 | 57 (9.71) | 0.66 (0.43–1.01) | 0.054 | 276 | 26 (9.42) | 0.57 (0.33–1.01) | 0.055 | 863 | 83 (9.62) | 0.65 (0.46–0.90) | 0.010 |
| Number of protective genotypesd | ||||||||||||
| 0 | 108 | 20 (18.52) | 1.00 | 51 | 16 (31.37) | 1.00 | 159 | 36 (22.64) | 1.00 | |||
| 1 | 367 | 41 (11.17) | 0.58 (0.34–1.00) | 0.050 | 173 | 18 (10.40) | 0.30 (0.15–0.58) | 0.0004 | 540 | 59 (10.93) | 0.44 (0.29–0.67) | 0.0001 |
| 2 | 319 | 29 (9.09) | 0.37 (0.21–0.68) | 0.001 | 141 | 12 (8.51) | 0.24 (0.11–0.51) | 0.0002 | 460 | 41 (8.91) | 0.37 (0.24–0.58) | <0.0001 |
| 3 | 64 | 5 (7.81) | 0.15 (0.05–0.52) | 0.003 | 44 | 2 (4.55) | 0.13 (0.03–0.56) | 0.006 | 108 | 7 (6.48) | 0.23 (0.10–0.52) | 0.0004 |
| Trend test | <0.001 | 0.0002 | <0.0001 | |||||||||
| 0–1 | 475 | 61 (12.84) | 1.00 | 224 | 34 (15.18) | 1.00 | 699 | 95 (13.59) | 1.00 | |||
| 2–3 | 383 | 34 (8.88) | 0.49 (0.31–0.76) | 0.002 | 185 | 14 (7.57) | 0.48 (0.26–0.90) | 0.021 | 568 | 48 (8.45) | 0.61 (0.43–0.86) | 0.0049 |
aAdjusted for age, sex, Breslow thickness, distant/regional metastasis, ulceration and mitotic rate in Cox models of SNPs and CMSS in the MDACC study.
bAdjusted for age and sex in the Harvard study.
cAdjusted for age and sex in MDACC and Harvard combined dataset.
dProtective genotypes were rs6750552 TT, rs6785564 AG+GG, rs2596191 CA+AA.