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. 2019 Apr 18;13(5):1249–1267. doi: 10.1002/1878-0261.12483

Figure 3.

Figure 3

MiR‐122 promotes radiosensitivity in parental breast cancer cells. Increased expression of miR‐122 in parental (A) MCF‐7 and (B) MDA‐MB‐231 cells transfected with mimic‐miR122 was verified by qRT‐PCR assays. All values were normalized using RNU44 as an internal control. Mimic‐miR122‐transfected cells were evaluated for a radioresponse by clonogenic survival. Data for SF of transfected (C) MCF‐7 and (D) MDA‐MB‐231 cells irradiated (+IR) with 4 Gy of X‐ray are shown. Data were normalized using non‐irradiated cells (−IR). Representative images of the clonogenic assays results of MCF‐7 and MDA‐MB‐231 cells are shown in (C) and (D). Data are presented as the mean ± SD of three independent experiments. *P < 0.05; **P < 0.01 by ANOVA. (E) Kaplan–Meier analysis of the breast cancer patients with tumors positive or negative for miR‐122 expression who received radiotherapy treatment. Curves were compared using a log‐rank test *P < 0.01. Rpm, reads per million.