Table 2.

Verified targets genes of miRNAs modulated in MCF‐7RR cells

	Genes
Down‐regulated
hsa‐miR‐196b	HOXB8, HOXC8, CD8A, HOXA9, HOXA9, MEIS1, FAS, ETS2, RDX, HOXB7
hsa‐miR‐146a	CXCR4, TLR2, FADD, TRAF6, IRAK1, ROCK1, BRCA2, BRCA1, NFKB1, CDKN1A, EGFR, CD40LG, FAS, ERBB4, SMAD4, TLR4, WASF2, STAT1, UHRF1, L1CAM, SMN1, CARD10, COPS8, ELAVL1, NUMB, PTGS2, CCL5, PTGES2, CNOT6L, SIKE1, CXCL12, PRKCE, RAC1, LAMC2, COX2, RNF11
hsa‐miR‐181a‐2*	Not reported
Up‐regulated
hsa‐miR‐222	STAT5A, CDKN1B, SOD2, MMP1, FOXO3, CDKN1C, KIT, PPP2R2A, TIMP3, FOS, ICAM1, ESR1, BBC3, PTEN, SELE, DIRAS3, ETS1, DICER1, RECK, TRPS1, CERS2, GJA1, SSX2IP, DKK2, VGLL4
hsa‐miR‐218	LAMB3, LASP1, IKBKB, SP1, VOPP1, BIRC6, ACTN1, STAM2, CDKN1B, BIRC5, GJA1, ROBO1, RICTOR, SOST, SFRP2, HOXB3, DKK2, TOB1, CDK6, BMI1, LEF1, MITF, PDGFRA, GLI2, OTUD7B, RUNX2, CDH2, EGFR, RET, SH3GL1
hsa‐miR‐10a	HOXA1, USF2, MAP3K7, BTRC, SRSF1, TRA2B, CHL1, PTEN, PIK3CG
hsa‐miR‐424*	Not reported
hsa‐miR‐449b	SIRT1, CCNE2, MET, GMNN, HDAC1
hsa‐miR‐411	Not reported
hsa‐miR‐135b	APC, KLF4, MAFB, CASR, PPP2R5C, SMAD5, LZTS1, MID1, MTCH2, ACVR1B, BMPR2, TGFBR1
hsa‐miR‐184	AKT2, INPPL1, NFATC2, SOX7, EIF2C2, MYC, BCL2, EZR
hsa‐miR‐122	CYP7A1, IGF1R, SRF, RAC1, RHOA, ANK2, NFATC2IP, ENTPD4, ANXA11, ALDOA, RAB6B, RAB11FIP1, FOXP1, MECP2, NCAM1, UBAP2, TBX19, AACS, DUSP2, ATP1A2, MAPK11, FUNDC2, AKT3, TPD52L2, GALNT10, G6PC3, AP3M2, SLC7A1, XPO6, FOXJ3, SLC7A11, TRIB1, EGLN3, NUMBL, ADAM17, DSTYK, FAM117B, BCL2L2, PRKAB1, ADAM10, ACVR1C, PRKRA, WNT1, PTPN1, NT5C3A, P4HA1, PKM, CLIC4, MEF2D, AXL, NOD2, FUT8
hsa‐miR‐222*	STAT5A, CDKN1B, SOD2, MMP1, FOXO3, CDKN1C, KIT, PPP2R2A, TIMP3, TNFSF10, FOS, ICAM1, ESR1, BBC3, PTEN, SELE, DIRAS3, ETS1, DICER1, RECK, TRPS1, CERS2, GJA1, SSX2IP, DKK2, ADAM1A, MGMT, VGLL4
hsa‐miR‐223*	Not reported
hsa‐miR‐934	Not reported
hsa‐miR‐135b*	APC, KLF4, MAFB, CASR, PPP2R5C, SMAD5, LZTS1, MID1, MTCH2, ACVR1B, BMPR2, TGFBR1