Table 1.
List of proteins differentially regulated in invaded nerves compared to noninvaded nerves (two‐tailed Student's t‐test, P < 0.05 and FC > 2.0). The mean of peak intensity values from five samples is shown. IN: invaded nerves, NIN: noninvaded nerves, and FC, fold change
| Protein ID | Gene name | Protein name | IN | NIN | P value | FC |
|---|---|---|---|---|---|---|
| P51659 | HSD17B4 | Peroxisomal multifunctional enzyme type 2 | 2.0E+06 | 0.0E+00 | 0 | |
| O00231 | PSMD11 | 26S proteasome non‐ATPase regulatory subunit 11 | 4.0E+06 | 0.0E+00 | 0.0001 | |
| P50440 | GATM | Glycine amidinotransferase, mitochondrial | 2.0E+06 | 0.0E+00 | 0.0005 | |
| P02647 | APOA1 | Apolipoprotein A‐I | 2.0E+08 | 6.0E+08 | 0.001 | 0.4 |
| P04040 | CAT | Catalase | 3.0E+07 | 6.0E+07 | 0.0012 | 0.4 |
| P59768 | GNG2 | Guanine nucleotide‐binding protein G subunit gamma‐2 | 2.0E+07 | 7.0E+06 | 0.0017 | 2.3 |
| P11166 | SLC2A1 | Solute carrier family 2 | 7.0E+06 | 5.0E+07 | 0.0036 | 0.2 |
| P07339 | CTSD | Cathepsin D | 6.0E+07 | 3.0E+07 | 0.0037 | 2.0 |
| Q8TAT6 | NPLOC4 | Nuclear protein localization protein 4 homolog | 2.0E+07 | 2.0E+06 | 0.004 | 8.1 |
| P54577 | YARS | Tyrosine–tRNA ligase, cytoplasmic | 2.0E+06 | 3.0E+05 | 0.004 | 7.6 |
| P48681 | NES | Nestin | 4.0E+08 | 1.0E+08 | 0.0048 | 3.4 |
| P13521 | SCG2 | Secretogranin II | 3.0E+07 | 3.0E+06 | 0.0064 | 9.6 |
| P19971 | TYMP | Thymidine phosphorylase | 6.0E+07 | 2.0E+07 | 0.0064 | 2.4 |
| P08294 | SOD3 | Extracellular superoxide dismutase [Cu‐Zn] | 3.0E+06 | 1.0E+07 | 0.0069 | 0.2 |
| Q00325 | SLC25A3 | Phosphate carrier protein, mitochondrial | 8.0E+06 | 2.0E+06 | 0.0072 | 3.4 |
| P68871 | HBB | Hemoglobin subunit beta; LVV‐hemorphin‐7 | 1.0E+09 | 8.0E+09 | 0.0078 | 0.2 |
| P01857 | IGHG1 | Ig gamma‐1 chain C region | 1.0E+08 | 3.0E+08 | 0.0079 | 0.4 |
| P21796 | VDAC1 | Voltage‐dependent anion‐selective channel protein 1 | 1.0E+07 | 5.0E+06 | 0.008 | 2.4 |
| P02730 | SLC4A1 | Band 3 anion transport protein | 6.0E+05 | 1.0E+07 | 0.0083 | 0.0 |
| O15240 | VGF | Neurosecretory protein VGF | 1.0E+08 | 3.0E+07 | 0.0086 | 5.2 |
| P24821 | TNC | Tenascin | 5.0E+07 | 2.0E+07 | 0.0088 | 2.6 |
| P11277 | SPTB | Spectrin beta chain, erythrocyte | 2.0E+05 | 2.0E+06 | 0.0098 | 0.1 |
| Q9HCJ6 | VAT1L | Synaptic vesicle membrane protein VAT‐1 homolog‐like | 2.0E+07 | 5.0E+06 | 0.0111 | 2.8 |
| P45880 | VDAC2 | Voltage‐dependent anion‐selective channel protein 2 | 1.0E+07 | 7.0E+06 | 0.0118 | 2.0 |
| Q9UHG2 | PCSK1N | ProSAAS; KEP | 3.0E+07 | 6.0E+06 | 0.0123 | 4.7 |
| P54920 | NAPA | Alpha‐soluble NSF attachment protein | 5.0E+06 | 2.0E+06 | 0.0123 | 2.2 |
| Q01484 | ANK2 | Ankyrin‐2 | 5.0E+07 | 2.0E+07 | 0.0126 | 2.1 |
| P36543 | ATP6V1E1 | V‐type proton ATPase subunit E 1 | 9.0E+06 | 4.0E+06 | 0.0133 | 2.3 |
| O15075 | DCLK1 | Serine/threonine protein kinase DCLK1 | 4.0E+06 | 9.0E+05 | 0.0142 | 4.3 |
| P06727 | APOA4 | Apolipoprotein A‐IV | 3.0E+07 | 7.0E+07 | 0.015 | 0.5 |
| Q9UI12 | ATP6V1H | V‐type proton ATPase subunit H | 6.0E+06 | 3.0E+06 | 0.0154 | 2.2 |
| P02042 | HBD | Hemoglobin subunit delta | 1.0E+07 | 1.0E+08 | 0.0155 | 0.1 |
| P00918 | CA2 | Carbonic anhydrase 2 | 5.0E+05 | 7.0E+06 | 0.0155 | 0.1 |
| Q9NTK5 | OLA1 | Obg‐like ATPase 1 | 3.0E+06 | 7.0E+05 | 0.0169 | 3.5 |
| P69905 | HBA1 | Hemoglobin subunit alpha | 8.0E+08 | 4.0E+09 | 0.0179 | 0.2 |
| P61803 | DAD1 | Dolichyl‐diphosphooligosaccharide–protein glycosyltransferase subunit DAD1 | 4.0E+06 | 1.0E+06 | 0.019 | 3.8 |
| Q15063 | POSTN | Periostin | 1.0E+08 | 4.0E+07 | 0.0201 | 3.5 |
| P01834 | IGKC | Ig kappa chain C region | 7.0E+07 | 2.0E+08 | 0.0202 | 0.4 |
| P17174 | GOT1 | Aspartate aminotransferase, cytoplasmic | 2.0E+07 | 7.0E+06 | 0.0223 | 2.4 |
| P00915 | CA1 | Carbonic anhydrase 1 | 7.0E+06 | 4.0E+07 | 0.0232 | 0.2 |
| P00450 | CP | Ceruloplasmin | 2.0E+07 | 5.0E+07 | 0.024 | 0.4 |
| P02790 | HPX | Hemopexin | 5.0E+07 | 9.0E+07 | 0.0266 | 0.5 |
| P17096 | HMGA1 | High mobility group protein HMG‐I/HMG‐Y | 3.0E+07 | 6.0E+06 | 0.0271 | 5.2 |
| Q15631 | TSN | Translin | 3.0E+06 | 7.0E+06 | 0.0287 | 0.5 |
| P48163 | ME1 | NADP‐dependent malic enzyme | 2.0E+06 | 5.0E+05 | 0.0289 | 3.6 |
| Q16799 | RTN1 | Reticulon‐1 | 1.0E+07 | 5.0E+06 | 0.0307 | 2.5 |
| P17677 | GAP43 | Neuromodulin | 2.0E+08 | 9.0E+07 | 0.0311 | 2.1 |
| O75348 | ATP6V1G1 | V‐type proton ATPase subunit G 1 | 9.0E+06 | 4.0E+06 | 0.034 | 2.1 |
| O00154 | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | 1.0E+07 | 4.0E+06 | 0.0342 | 2.8 |
| Q9NZN4 | EHD2 | EH domain‐containing protein 2 | 7.0E+06 | 5.0E+07 | 0.0347 | 0.1 |
| P00747 | PLG | Plasminogen | 7.0E+06 | 2.0E+07 | 0.0357 | 0.4 |
| P05156 | CFI | Complement factor I | 1.0E+06 | 7.0E+06 | 0.0368 | 0.2 |
| O60716 | CTNND1 | Catenin delta‐1 | 3.0E+06 | 5.0E+05 | 0.0374 | 6.3 |
| Q1KMD3 | HNRNPUL2 | Heterogeneous nuclear ribonucleoprotein U‐like protein 2 | 2.0E+06 | 4.0E+05 | 0.0377 | 4.2 |
| P20591 | MX1 | Interferon‐induced GTP‐binding protein Mx1 | 8.0E+06 | 2.0E+06 | 0.0389 | 4.1 |
| P40121 | CAPG | Macrophage‐capping protein | 1.0E+07 | 2.0E+06 | 0.0401 | 5.2 |
| Q01118 | SCN7A | Sodium channel protein type 7 subunit alpha | 4.0E+06 | 2.0E+07 | 0.0408 | 0.2 |
| Q86Y82 | STX12 | Syntaxin‐12 | 1.0E+06 | 0.0E+00 | 0.042 | |
| Q9P0J7 | KCMF1 | E3 ubiquitin–protein ligase KCMF1 | 3.4E+05 | 0.0E+00 | 0.0426 | |
| P05546 | SERPIND1 | Heparin cofactor 2 | 2.0E+06 | 7.0E+06 | 0.0493 | 0.3 |
| P18509 | ADCYAP1 | Pituitary adenylate cyclase‐activating polypeptide | 7.0E+06 | 0.0E+00 | 0.0499 |
Proteins in bold were selected for IHC validation.