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Proposed model for CHIP‐mediated ubiquitylation and degradation of Snail in ovarian tumor cells. In normal or early‐stage tumor cells, CHIP is highly expressed and effectively degrades Snail through ubiquitylation, contributing to reduced EMT (left). In malignant tumor cells, CHIP expression is repressed by promoter hypermethylation, and increased nuclear Snail protein induces EMT (right).
