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. 2019 Apr 26;15:1744806919838947. doi: 10.1177/1744806919838947

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Effects of intrathecal MK801-3, MK801-10, and MEM-30 following SNI.(a) Pretreatment with MK801-3 prevented the induction of punctate allodynia at day 1 after SNI surgery and MK801-10 prevented the induction of punctate allodynia at day 3 (two-way ANOVA with Bonferroni post hoc, vehicle vs. MK801-3, p = 0.0088; vehicle vs. MK801-10, p = 0.0096). MK801-3 exerted no effects on the induction of dynamic allodynia (two-way ANOVA with Bonferroni post hoc, p = 0.1583). MK801-10 prevented the induction of dynamic allodynia (two-way ANOVA with Bonferroni post hoc, p = 0.0057). Vehicle, n = 12; MK801-3, n = 14; MK801-10, n = 5. (b) Pretreatment with MEM-30 prevented the induction of punctate allodynia (two-way ANOVA with Bonferroni post hoc, vehicle vs. MEM-30, p = 0.0039) and dynamic allodynia (two-way ANOVA with Bonferroni post hoc, vehicle vs. MEM-30, p = 0.0001). Graphs represent the mean response ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001, MEM-30 or MK801-3 vs. vehicle group. ^#p < 0.05; ^###p < 0.001, MK801-10 versus vehicle group; ^&&p < 0.01, MK801-3 versus MK801-10 group. MEM: memantine.