Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 26;15:1744806919838947. doi: 10.1177/1744806919838947

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 4. — CFA injection did not increase the activation of microglia in dorsal spinal cord of mice and MEM-10 showed no changes on the induction of dynamic allodynia following CFA injection. (a) Microglial immunostaining against Iba-1 in mice spinal cord dorsal horns after CFA injection and MEM-10 administration. (b) The histograms, respectively, show the quantification of ratio of immunostaining density on ipsilateral (ipsi) and control (cont) sides of dorsal spinal cord after CFA injection. (c) Punctate allodynia was prevented by MEM-10 injection (one-way ANOVA with Bonferroni post hoc, p = 0.0096) and dynamic allodynia was not affected by MEM-10 injection (one-way ANOVA with Bonferroni post hoc, p = 0.2512). Vehicle, n = 5; MEM-10, n = 9. Graphs represent the mean response ± SEM. *p < 0.05. MEM: memantine; CFA: complete freund′s adjuvant.