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. 2019 Apr 26;15:1744806919838947. doi: 10.1177/1744806919838947

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Loss of brush-induced dynamic allodynia in ML133 injection mice following SNI. (a) Kir 2.1 channel expressed in the membrane of microglia in dorsal spinal cord lamina I and II. Immunohistochemistry confocal scanning in ipsilateral lumbar spinal cord between Kir2.1 (red) and Iba-1 (green) showed the distribution of Kir2.1 channel in spinal cord dorsal horn. Three confocal images are zoom-in images from area in top red square. White arrows showed the co-localization of Kir2.1 channel and microglia. (b) ML133 prevented the induction of dynamic allodynia following SNI (two-way ANOVA with Bonferroni post hoc, p = 0.0002) and had no effect on the induction of punctate allodynia (two-way ANOVA with Bonferroni post hoc, p = 0.7237). Vehicle, n = 7; ML133, n = 6. Graphs represent the mean response ± SEM. ***p < 0.001.