Figure 2.

Pulmonary inflammation is largely unaltered, airway neutrophil numbers are reduced, airway remodelling is increased in association with Il33 and Il13 mRNA expression, and emphysema‐like alveolar enlargement is inhibited in ILC2‐deficient mice exposed to CS. Mice were lavaged and (A) total BAL cells, (B) monocytes/macrophages, (C) neutrophils, and (D) lymphocytes were enumerated. Representative images and quantification of (E) collagen and (F) alveolar diameter in normal air‐ or CS‐exposed WT and Rora^fl/flIl7r^Cre (ILC2‐deficient) mice. Whole lung (G) Il33 mRNA expression, (H) IL‐33 protein levels, and (I) Il13 mRNA expression. n = 4–8 per group. Data are expressed as mean ± sem. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001