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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Virology. 2019 Mar 30;531:260–268. doi: 10.1016/j.virol.2019.03.018

Fig. 7. SAMHD1 blocks infection by HIV-1-G208R.

Fig. 7

(A) THP-1 and THP-1-MxB-KO cells were challenged with increasing amounts of HIV-1 or HIV-1-G208R expressing GFP as a reporter of infection. G208R is a mutation in the capsid protein that prevents the interaction of HIV-1 with MxB during infection. Wild type and mutant viruses were normalized for p24. The percentage of GFP-positive cells was measured by flow cytometry at 48 h post-challenge. Similar results were obtained in three independent experiments and a representative experiment is shown. (B) Infection of HIV-1-G208R in THP-1-MxB-KO clones is shown. The results of three independent experiments with standard deviation are shown. * denotes P-value of < 0.0001, ns denotes not significant as determined by One-way ANOVA Tukey’s multiple comparisons test.