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. Author manuscript; available in PMC: 2019 Apr 29.
Published in final edited form as: J Alzheimers Dis. 2018;66(3):971–981. doi: 10.3233/JAD-180302

Fig. 3.

Fig. 3.

Plasma NDE concentrations of Aβ1-42, NRGN, synaptophysin, synaptotagmin, and synaptopodin demonstrated the highest diagnostic accuracy for distinguishing between MCI and CNC patients as measured by ROC analysis. Representative ROC curves for plasma NDE concentrations for Aβ1-42, NRGN, synaptophysin, synaptotagmin, and synaptopodin for placebo-treated, MCI patients as compared to placebo-treated, CNC patients (A) and GHRH-treated, MCI patients as compared to GHRH-treated, CNC patients (B). Aβ1-42, NRGN, synaptophysin, synaptotagmin, and synaptopodin demonstrate the highest diagnostic accuracy for distinguishing CNC and MCI patients, independent of GHRH treatment. Plasma NDE concentrations of Aβ1-42, ptau-S396, NRGN, synaptopodin, and GAP43 (C) demonstrated the lowest diagnostic accuracy for distinguishing between placebo-treated and GHRH-treated, MCI patients. Plasma NDE concentrations for a synaptophysin and synaptotagmin demonstrated moderate diagnostic accuracy for distinguishing between placebo-treated and GHRH-treated, MCI patients (D).