Table 2. Association of Type and Duration of Antimicrobial Prophylaxis With Surgical Site Infection.
| Variable | aOR (95% CI) |
|---|---|
| Cardiac Surgerya | |
| Antimicrobial type | |
| β-Lactam | 1 [Reference] |
| Vancomycin + aminoglycoside | 1.29 (0.52-3.20) |
| Aminoglycoside | 2.35 (0.72-7.62) |
| Vancomycin | 0.73 (0.57-0.93) |
| Other | 2.83 (0.68-11.83) |
| Antimicrobial duration, h | |
| <24 | 1 [Reference] |
| 24-<48 | 0.96 (0.71-1.29) |
| 48-<72 | 0.73 (0.42-1.30) |
| ≥72 | 0.99 (0.49-2.00) |
| Orthopedic Surgeryb,c | |
| Antimicrobial type | |
| β-Lactam | 1 [Reference] |
| Vancomycin + aminoglycoside | 1.26 (0.57-2.80) |
| Aminoglycoside | 0.74 (0.40-1.35) |
| Vancomycin | 1.00 (0.80-1.26) |
| Other | 1.23 (0.80-1.89) |
| Antimicrobial duration, h | |
| <24 | 1 [Reference] |
| 24-<48 | 1.11 (0.82-1.51) |
| 48-<72 | 2.04 (1.00-4.16) |
| ≥72 | 1.63 (0.22-12.07) |
| Colorectal Surgeryb,d | |
| Antimicrobial type | |
| β-Lactam | 1 [Reference] |
| Vancomycin + aminoglycoside | 2.53 (0.97-6.61) |
| Aminoglycoside | 1.12 (0.68-1.86) |
| Vancomycin | 1.17 (0.85-1.60) |
| Other | 1.21 (0.97-1.52) |
| Antimicrobial duration, h | |
| <24 | 1 [Reference] |
| 24-<48 | 0.87 (0.73-1.04) |
| 48-<72 | 0.81 (0.60-1.09) |
| ≥72 | 0.96 (0.52-1.79) |
| Vascular Surgeryb,e | |
| Antimicrobial type | |
| β-Lactam | 1 [Reference] |
| Vancomycin + aminoglycoside | 0.49 (0.19-2.07) |
| Aminoglycoside | 0.50 (0.18-1.40) |
| Vancomycin | 0.89 (0.72-1.11) |
| Other | 0.97 (0.63-1.49) |
| Antimicrobial duration, h | |
| <24 | 1 [Reference] |
| 24-<48 | 0.95 (0.81-1.21) |
| 48-<72 | 1.27 (0.87-1.86) |
| ≥72 | 0.48 (0.15-1.56) |
Abbreviation: aOR, adjusted odds ratio.
a
Model adjusted for age, sex, race, diabetes, smoking status, American Society of Anesthesiologists score greater than 2, methicillin-resistant Staphylococcus aureus colonization status, mupirocin receipt, and facility median duration of surgical prophylaxis for cardiac procedures only. Model C statistic, 0.64.
b
Model adjusted for age, sex, race, diabetes, smoking status, American Society of Anesthesiologists score greater than 2, methicillin-resistant Staphylococcus aureus colonization status, mupirocin receipt, and facility median duration of surgical prophylaxis for noncardiac procedures only.
c
Model C statistic, 0.60.
d
Model C statistic, 0.58.
e
Model C statistic, 0.61.