Figure 2. Estimates of Coronary Heart Disease (CHD) Risk Reduction With Lowering of Lipoprotein(a) (Lp[a]) Concentration.

The solid lines provide the genetically predicted lifelong reduction of CHD risk by varying amount of genetically caused Lp(a) reductions. The blue lines provide data from Burgess et al⁹ and the orange lines are based on the estimates from our study. The dashed lines give the predicted short-term trial estimates from both studies. The intersections of the horizontal and vertical dotted lines illustrate the required amount of Lp(a) lowering to reach the same effect on clinical outcomes as a 38.67 mg/dL genetically caused reduction of LDL-C (corresponds to 45% risk reduction) or therapeutic reduction of LDL-C derived from the CTT trial¹³ (corresponds to 22% risk reduction).

SI conversion factor: To convert cholesterol levels to millimoles per liter, multiply by 0.0259.