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. 2019 Apr 25;5(6):872–878. doi: 10.1001/jamaoncol.2019.0192

Table. Pain Response Over Time by Treatment Group.

Group Patients, No. (%)
2 Weeks 1 Month 3 Months 6 Months 9 Months
Single Fx Multifx P Value Single Fx Multifx P Value Single Fx Multifx P Value Single Fx Multifx P Value Single Fx Multifx P Value
Intent-to-Treat Population
Responders (CR + PR) 34 of 81 (42) 19 of 79 (24) .03 36 of 81 (44) 24 of 79 (30) .18 31 of 81 (38) 17 of 79 (21) .05 19 of 81 (23) 17 of 79 (21) .89 17 of 81 (21) 12 of 79 (15) .06
Nonresponders (PP + IR) 21 of 81 (26) 33 of 79 (42) 17 of 81 (21) 20 of 79 (25) 12 of 81 (15) 18 of 79 (23) 9 of 81 (11) 11 of 79 (14) 5 of 81 (6) 14 of 79 (18)
Per-Protocol Treated Population
Responders (CR + PR) 34 of 55 (62) 19 of 52 (36) .01 36 of 44 (68) 24 of 44 (45) .21 31 of 43 (72) 17 of 35 (49) .03 19 of 28 (68) 17 of 28 (61) .78 17 of 22 (77) 12 of 26 (46) .04
Nonresponders (PP + IR) 21 of 55 (38) 33 of 52 (64) 36 of 44 (68) 20 of 44 (45) 12 of 43 (28) 18 of 35 (51) 9 of 28 (32) 11 of 28 (39) 5 of 22 (23) 14 of 26 (54)

Abbreviations: CR, complete response; Fx, (radiation) fraction; IR, indeterminate response; PP, pain progression; PR, partial response.

Pain response was scored as both change in pain score (assessed on a 0-to-10 scale) and use of analgesics per the International Consensus Criteria.10,11