A, Incidences of the most common all-grade adverse events. B, Incidences of the most common grade 3 or higher adverse events. C, Incidences of the most common all-grade irAEs. D, Incidences of the most common grade 3 or higher irAEs. Vertical lines in A and C indicate the overall mean incidence of all-grade adverse events (1.66%). Vertical lines in B and D indicate the overall mean incidence of grade 3 or higher adverse events (0.11%). Values to the left of the line are lower than the mean, to the right, higher. ALT indicates alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyltransferase.