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. 2019 Mar 28;597(9):2337–2360. doi: 10.1113/JP277335

Figure 13. Effects of CaCCinh‐A01 on intestinal slow waves from juvenile mice.

Figure 13

A, concentration‐dependent effects of CaCCinh‐A01 on intestinal slow waves from P9–P11animals. B–E, effects of CaCCinh‐A01 on slow wave amplitude, frequency, half‐maximal duration and maximal rate of rise. B, reduction in slow wave amplitude (mV) reached statistical significance at 1 μM. C, reduction in slow wave frequency (cycles min−1) reached statistical significance at 5 μM. D, half‐maximal duration of slow wave duration (s) was reduced at 5 μM. E, statistically significant reduction in the maximal rate of rise of the slow wave upstroke (dV/dt; mV s−1) was reached at 3 μM CaCCinh‐A01. Data shown in B–E are means ± SEM; n = 6. * P<0.05; ** P<0.01; *** P<0.001; one‐way ANOVA. Juvenile small intestinal muscles are much more sensitive to the Ano1 antagonist than adult muscles (Hwang et al. 2016).