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. 2019 Feb 27;597(9):2361–2378. doi: 10.1113/JP277336

Figure 2. Antibiotic treatment restores vascular endothelial function in old mice via improved NO bioavailability.

Figure 2

A, dose–response endothelium‐dependent dilatation (EDD) to acetylcholine (ACh). B, peak NO‐mediated dilatation to ACh, assessed as the difference between peak EDD in the absence vs. presence of the NO synthase inhibitor l‐NAME. C, dose–response endothelium independent dilatation to the NO donor SNP. Data are the mean ± SEM. * P < 0.05 vs. YC. YC, young control; YA, young antibiotic‐treated; OC, old control; OA, old antibiotic‐treated.