Table 1.
Gene | Normoxia | Hypoxia | |
---|---|---|---|
Ppia | 32234 ± 2363 | 28269 ± 3394 | NS |
P53 | 10775 ± 1237 | 13417 ± 1332 | 0.09 |
P21 | 5188 ± 1053 | 9292 ± 1374 | 0.04 |
Alox12 | 3120 ± 744 | 7714 ± 2089 | 0.05 |
Alox15 | 925 ± 225 | 854 ± 147 | NS |
Ogg1 | 1294 ± 135 | 1710 ± 132 | 0.03 |
Neil1 | 769± 63 | 730 ± 117 | NS |
Nth1 | 1505 ± 27 | 1329 ± 151 | NS |
Xrrc1 | 2675 ± 375 | 2175 ± 372 | NS |
Nrf2 | 11560 ± 1704 | 7555 ± 893 | NS |
Dna pkcs | 2134 ± 323 | 1421 ± 192 | 0.1 |
Mre11 | 723 ± 119 | 307 ± 79 | 0.04 |
Ku70 | 2380 ± 397 | 1533 ± 389 | NS |
Ku80 | 8743 ± 1410 | 5709 ± 1219 | NS |
Bax | 2093 ± 199 | 1750 ± 329 | NS |
Bcl2 | 4036 ± 530 | 2599 ± 293 | 0.05 |
BaxBcl2 | 0.41 ± 0.02 | 0.5 ± 0.08 | NS |
Tfam | 6447 ± 844 | 3866 ± 632 | 0.04 |
Pgc1a | 1806 ± 121 | 903 ± 236 | 0.01 |
Cs | 18621 ± 2551 | 9627 ± 156 | 0.02 |
Lonp1 | 7518 ± 874 | 7262 ± 1035 | NS |
Cycs | 27321 ± 4613 | 15812 ± 4446 | 0.08 |
Complex I | 26745 ± 721 | 22123 ± 2086 | 0.01 |
Complex II | 19112 ± 3730 | 14311 ± 1389 | NS |
Complex III | 27555 ± 4854 | 18414 ± 1721 | NS |
Complex IV | 46402 ± 4883 | 33668 ± 1533 | 0.05 |
Hif | 8172 ± 791 | 8276 ± 628 | NS |
Gp91phox | 6191 ± 1727 | 6904 ± 1023 | NS |
P22phox | 5128 ± 1081 | 7298 ± 1030 | NS |
P47phox | 1887 ± 136 | 2620 ± 631 | NS |
Xo | 19493 ± 2381 | 15989 ± 1793 | NS |
Gpx1 | 67342 ± 11501 | 34576 ± 8409 | NS |
Hmox1 | 3492 ± 202 | 3720 ± 255 | NS |
Catalase | 12593 ± 1716 | 13651 ± 280 | NS |
Nfkβ | 6419 ± 476 | 6073 ± 307 | NS |
Mnsod | 9286 ± 2005 | 15399 ± 577 | 0.04 |
Cuznsod | 171954 ± 8398 | 160528 ± 13018 | NS |
Ecsod | 35354 ± 3730 | 23778 ± 3163 | NS |
n = 7–8 for all groups (n refers to the number of litters). NS, not significant.
All reported P values have been adjusted to take account of multiple hypothesis testing.