Figure 11. Low glucose‐induced depolarization of NTS neurons is short living and reversed by the opening of K_ATP channels.

A, subset of neurons initially responsive to low glucose is hyperpolarized after a long period of exposure, as shown by a representative recording (Aa). Note that tolbutamide reverses the hyperpolarizing effect induced by low glucose. Ab, summary of the effect triggered by low glucose and tolbutamide on the membrane potential (V _m) of neurons. B, a neuron non‐responsive to a low glucose challenge is hyperpolarized after more than 20 min low glucose exposure. Note that tolbutamide also reverses the hyperpolarizing effect. C, application of tolbutamide suppresses the hyperpolarization induced by a long period of low glucose perfusion, as shown by a representative recording (Ca). Cb, summary of the effect of low glucose and tolbutamide on V _m of neurons. Tolb, tolbutamide; TTX, tetrodotoxin. ^* P < 0.05. [Color figure can be viewed at wileyonlinelibrary.com]