Table 4.

Kinetic rate constants

	A	B	C	2πb (s−1)	2πc (s−1)
Control	339 ± 23	741 ± 73	923 ± 76	1036 ± 34.8	5376 ± 168
R249Q/R249Q line 19	277 ± 18	312 ± 31*	945 ± 164	690 ± 23.3*	21272 ± 5034*
R249Q/R249Q line 12	280 ± 25	272 ± 26*	664 ± 52*	697 ± 26.2*	14378 ± 2362*
R249Q/+	234 ± 19*	504 ± 54* , +	696 ± 34	1123 ± 31.6* , +	7775 ± 525+

A, B, C, b, and c are derived from eqn (1), and are the average of the values (± SEM) taken from the sinusoid experimental run that generated maximum power for each fibre. 2πb and 2πc are muscle apparent rate constants for work generating and work absorbing steps of the cross‐bridge cycle, respectively (see Fig. 1). ^*Significant difference from the control; ⁺significant difference between R249Q/R249Q line 19 homozygous, and heterozygous lines; ^#significant difference between R249Q/R249Q line 12 and R249Q/R249Q line 19 (one‐way ANOVA; P < 0.05). n = 12 for control, R249Q/R249Q line 19, and R249Q/+ fibres. n = 8 for R249Q/R249Q line 12. The data set of individual fibre values used to calculate these average kinetic rate constants can be found in the fifth tab of Supplemental File S1 in Supporting Information.