Table 1.
Animal models of malaria and salmonella coinfection
| Reference | Animal (strain) | Plasmodium spp. | NTS strain (serovar) | Route of NTS challenge | NTS challenge after Plasmodium | Endpoint | NTS‐related outcome |
|---|---|---|---|---|---|---|---|
| Roux et al.77 | Mus (CBA/J) | P. yoelii nigeriensis | IR715 (ATCC 14028) | Intragastric | Day 0 | Day 5 | Increased CFU in Spleen, liver, and Peyer's patch. |
| Cunnington et al.63 | Mus (C57BL/6) | P. yoelii 17XNL | 12023‐GFP | Intraperitoneal | Day 15 | 18 h | Increased CFU in blood, spleen, and liver. |
| Chau et al.124 | Mus (CBA/J) | P. yoelii 17XNL | IR715 (ATCC 14028) | Intragastric | Day 10 | Day 14 | l‐Arginine & l‐Citrulline supplementation during P.y. reduces NTS burden in mesLN |
| Lokken et al.64 | Mus (CBA/J) | P. yoelii nigeriensis | IR715 (ATCC 14028) | Intragastric | Day 10 | Day 12, 14 | Increased CFU in liver (day 12/14), blood (day 14) |
| Mus (CBA/J) | Intraperitoneal | Day 10 | Day 12, 13 | Increased CFU in liver (day 12/13), blood (day 13) | |||
| Mus (C57BL/6J) | Intragastric | Day 10 | Day 12 | No increase in CFU, reduced liver PMN chemokines | |||
| Mus (C57BL/6J) | Intraperitoneal | Day 10 | Day 12 | No increase in CFU | |||
| Mus (C57BL/6J il10–/–) | Intragastric | Day 10 | Day 12 | Reduces CFU in single & co‐infected, restored liver PMN chemokines | |||
| Mus (C57BL/6J il10Rflx:LysMcre) | Intraperitoneal | Day 10 | Day 12 | IL‐10R–/– myeloid cells; loss in increased liver, blood CFU | |||
| Mus (C57BL/6J il10flx:LysMcre) | Intraperitoneal | Day 10 | Day 12 | IL‐10–/– myeloid cells; loss in increased blood CFU | |||
| Mooney et al.59 | Macaca mulatta | P. fragile | IR715 (ATCC 14028) | Ligated ilieal loops | Day 14, 15 | 8 h | Reduced intestinal inflammation to NTS |
| Mus (CBA/J) | P. yoelii nigeriensis | Intragastric | Day 10 | Day 12 | Reduced intestinal inflammation to NTS, increased mesLN CFU | ||
| Mus (C57BL/6J) | Day 10 | Day 12 | Reduced intestinal inflammation & PMN influx | ||||
| Mus (C57BL/6J il10–/–) | Day 10 | Day 12 | Restored intestinal inflammation & PMN influx in IL‐10–/– | ||||
| Mooney et al.125 | Mus (C57BL/6) | P. yoelii 17XNL | BRD509 | Intravenous | Day 14, 28 | Day 17, 31 | Increased CFU in liver |
| Mus (C57BL/6J‐Slc11a1+/+) | Intravenous | Day 14 | Day 17 | No increase in CFU | |||
| Mus (CBA/J) | Intragastric | Day 14 | Day 18 | No increase in CFU | |||
| Mooney et al.62 | Mus (C57BL/6J) | P. yoelii nigeriensis | IR715 (ATCC 14028) | Intragastric | Day 10 | Day 11 | Increased NTS colonization in feces |
| Mus (C57BL/6J) ‐ Germ Free | Day 10 | Day 11 | Increased NTS colonization in feces with fecal donation from P. yoelii‐infected mice into germ‐free mice | ||||
| Lokken et al.79 | Mus (CBA/J) | P. yoelii nigeriensis | IR715 (ATCC 14028) | Intragastric | Day 10 | Day 12, 14 | Increased CFU in liver (day 14 only) |
| Mus (C57BL/6J il10–/–) | Intraperitoneal | Day 10 | Day 12 | Reduced CFU in liver in IL‐10–/– |