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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Exp Eye Res. 2018 Apr 25;173:64–72. doi: 10.1016/j.exer.2018.04.015

Fig. 9. Schemetic diagram of signaling pathways activated by RvE1.

Fig. 9

RvE1 binds to the ERV-1/ChemR23receptor and activates the signaling pathways of PLA2, PLD, and PLC. PLA2 and PLD activation increases [Ca2+]i. PLC increases IP3 and DAG. IP3 releases Ca2+ while DAG activates PKC. Activation of these pathways lead to mucin secretion. PLA2-phospholipase A2; PLD-phospholipase D; PLC-phospholipase C; IP3-inositol trisphosphate; DAG-diacylglycerol; PKC-protein kinase C.