Table 1.
The difference in time spent in the cocaine-paired chamber prior to conditioned place preference (CPP) and the total ambulations (horizontal beam-breaks) in the CPP apparatus following conditioning among proestrous or diestrous GT-tg female mice (n = 16-20/group) that were administered vehicle saline (0.9 %, i.p., for 7 days) as uninduced controls or doxycycline (DOX; 25 - 125 mg/kg, i.p., 7 days) to induce HIV-1 Tat1-86 expression.
| Proestrus | Diestrus | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Saline | DOX 25 mg/kg |
DOX 50 mg/kg |
DOX 100 mg/kg |
DOX 125 mg/kg |
Saline | DOX 25 mg/kg |
DOX 50 mg/kg |
DOX 100 mg/kg |
DOX 125 mg/kg |
|
| Pre-CPP Time Difference in Cocaine-Chamber (s ± SEM) | −2 ± 43 | −16 ± 50 | 10 ± 52 | −68 ± 67 | −89 ± 52 | −6 ± 44 | −36 ± 54 | −41 ± 66 | 24 ± 38 | −14 ± 57 |
| Total Ambulations in CPP Apparatus (mean ± SEM) | 1472 ± 32 | 1452 ± 62 | 1351 ± 68 | 1437 ± 139 | 1373 ± 66 | 1504 ± 67 | 1383 ± 32 | 1326 ± 60 | 1321 ± 130 | 1384 ± 57 |