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. Author manuscript; available in PMC: 2020 Jan 9.
Published in final edited form as: J Am Chem Soc. 2018 Dec 21;141(1):163–167. doi: 10.1021/jacs.8b13030

Table 4.

Pd-Catalyzed Enantioselective Dearomative syn-1,4-Diaminationaa

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a

Standard reaction conditions: MTAD (1, 0.5 mmol, 1.0 equiv), naphthalene (5, 1.0 mmol, 2.0 equiv), EtOAc (0.1 M), visible light, −50 °C, 12 h; then addition of amine (1.0 mmol, 2.0 equiv) and Pd2(dba)3 (2.5 mol %) and (S,Sp)-tBu-Phosferrox (6.0 mol %) in THF, −20 °C, 20 h. Reported yields are of isolated products.