Table 1.

Independent predictors of survival identified by proportional hazards Cox regression analysis and locoregional lung adenocarcinoma death risk score (LADERS)

Variable	Hazard ratio (95% confidence interval)	Probability	Hazard points
Age <45 or >65 years	4.12 (2.35‐7.23)	0.0000008	3
FVCa <80% predicted	2.13 (1.25‐3.63)	0.0054374	1
DLCO/VA b <70% predicted	2.62 (1.60‐4.29)	0.0001292	2
N2c	3.56 (2.20‐5.76)	0.0000002	2.5
N3c	8.65 (1.10‐68.21)	0.0406576	7.5
Time to surgery >60 daysd	4.04 (2.07‐7.88)	0.0000408	3
Solid histologic subtypee	2.09 (1.27‐3.43)	0.0035422	1
LADERSf			0‐20

^aFVC, forced vital capacity. Compared with FVC ≥80% predicted. When FVC not available, GOLD COPD ≥stage II was used in the Tours cohort.

^bDL_CO/V_A, Lung diffusion capacity for carbon monoxide corrected for alveolar ventilation. Compared with DL_CO/V_A ≥70% predicted. When DL_CO/V_A not available, current smoking was used in the Tours cohort.

^cN, cTNM7 nodal status descriptors. Compared with pooled patients with N0 and N1.

^dCompared with patients operated within 60 days from diagnosis.

^eCompared with all other histologic subtypes combined, including lepidic, acinar, papillary, micropapillary, adenosquamous, fetal, and non‐specified.

^fRounded to the lower integer when decimal.