Table 2.

Unadjusted analyses testing differences in gene mutation frequencies between young adults and older lung adenocarcinoma patients

Gene	Young, n (%) n = 20	Older, n (%) n = 24	P‐value (Chi‐squared test or Fisher's exact test)
FRG1	8 (40.0)	3 (12.5)	0.0805
KMT2C (MLL3)	7 (35.0)	2 (8.3)	0.0573
KMT2D (MLL4)	2 (10.0)	1 (4.2)	0.583
KMT2E (MLL5)	2 (10.0)	3 (12.5)	1
KMT2C/KMT2D/KMT2E	10 (50.0)	4 (16.7)	0.042 a

KMT2C/KMT2D/KMT2E: represent numbers of individuals carrying mutations in at least one of the genes of KMT2C, KMT2D, and KMT2E.

P‐value: P‐values representing the differences of mutation frequencies in FRG1, KMT2C/KMT2D/KMT2E between young (aged ≤ 36 y) and older (aged > 50 y) patients were obtained using chi‐squared tests (2‐sided); P‐values representing the differences of mutation frequencies in KMT2C (MLL3), KMT2D (MLL4), KMT2E (MLL5) between young (age ≤ 36 y) and older (age > 50 y) patients were obtained using Fisher's exact tests. P  < 0.05 was considered to be statistically significant and shown in bold.

^a P < 0.05.